{"id":394,"date":"2022-01-14T01:44:55","date_gmt":"2022-01-13T22:44:55","guid":{"rendered":"https:\/\/eczbilgipaylasim.com\/?p=394"},"modified":"2022-12-04T18:29:25","modified_gmt":"2022-12-04T15:29:25","slug":"kariyerine-fare-zehiri-olarak-baslayan-ilac-warfarin","status":"publish","type":"post","link":"https:\/\/eczbilgipaylasim.com\/?p=394","title":{"rendered":"KAR\u0130YER\u0130NE FARE ZEH\u0130R\u0130 OLARAK BA\u015eLAYAN \u0130LA\u00c7: WARFAR\u0130N"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">1920&#8217;li y\u0131llarda, Amerika bozk\u0131rlar\u0131nda ya\u015fayan \u00e7ift\u00e7iler esrarengiz bir olayla kar\u015f\u0131la\u015ft\u0131lar: S\u0131\u011f\u0131r s\u00fcr\u00fcleri anlam veremedikleri bir nedenden dolay\u0131 ya\u015fam\u0131n\u0131 yitirmekteydi. Olay mahalline gelen iki veteriner, s\u0131\u011f\u0131rlar\u0131n i\u00e7 kanamadan dolay\u0131 \u00f6ld\u00fcklerini saptad\u0131lar. B\u00f6lgenin nemli iklim ko\u015fullar\u0131n\u0131 ve s\u0131\u011f\u0131rlar\u0131n besinlerini de g\u00f6z \u00f6n\u00fcnde bulunduran veterinerler, s\u00fcr\u00fcn\u00fcn otland\u0131klar\u0131 k\u00fcfl\u00fc tatl\u0131 su yoncas\u0131 saman\u0131n\u0131n (Melilotus officinalis) s\u0131\u011f\u0131rlarda hemorajik vakalara sebep oldu\u011funu d\u00fc\u015f\u00fcnd\u00fcler ve bir miktar numune alarak y\u00f6renin \u00fcnl\u00fc Biyokimyac\u0131s\u0131 Bay Karl Link&#8217;e ba\u015fvurdular. Bay Link, \u00e7al\u0131\u015fmalar\u0131 sonucu k\u00fcfl\u00fc samanda, do\u011fal bir madde olan kumarinin oksitlenerek olu\u015fan dikumarol maddesini ke\u015ffetti. \u00c7al\u0131\u015fma, 1941&#8217;de dikumarol i\u00e7in patent alan Wisconsin Mezunlar\u0131 Ara\u015ft\u0131rma Vakf\u0131 (WARF) taraf\u0131ndan finanse edildi. Fareler \u00fczerinde deneyler yapan Link, bile\u015fi\u011fin rodentisit amac\u0131yla kullanabilece\u011fini d\u00fc\u015f\u00fcnd\u00fc ve WARFAR\u0130N ad\u0131yla 1948&#8217;de bir Fare Zehiri olarak ba\u015far\u0131l\u0131 bir \u015fekilde pazarland\u0131.1951&#8217;de bir ABD Ordusu \u00fcyesi, rodentisit i\u00e7inde birden fazla dozda varfarin ile intihara te\u015febb\u00fcs etti. Acile kald\u0131r\u0131lan bu askerin y\u00fcksek doz kullanmas\u0131na ra\u011fmen h\u00e2l\u00e2 ya\u015f\u0131yor olmas\u0131 doktorlar\u0131 hayretler i\u00e7erisinde b\u0131rakt\u0131. Daha sonra varfarinin terap\u00f6tik bir antikoag\u00fclan olarak kullan\u0131m\u0131 \u00fczerine \u00e7al\u0131\u015fmalar ba\u015flad\u0131. 1955 y\u0131l\u0131nda ABD ba\u015fkan\u0131 Dwight D. Eisenhower&#8217;\u0131n kalp krizi ge\u00e7irmesi ve tedavide ilk defa varfarin&#8217;in kullan\u0131lmas\u0131 ilaca olan g\u00fcveni artt\u0131rd\u0131, o g\u00fcnden itibaren doktorlar kan p\u0131ht\u0131la\u015fmas\u0131n\u0131 \u00f6nlemek i\u00e7in bu bile\u015fi\u011fi ila\u00e7 olarak kullanmaya ba\u015flad\u0131.<br><br>Derleyen: Ecz. Faruk Ay<br>KAYNAK\u00c7A: Lim, G. Warfarin: Fare zehirinden klinik kullan\u0131ma. Nat Rev Cardiol (2017). <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1038\/nrcardio.2017.172?fbclid=IwAR1V0mbwcOe7pohRokqazyHWI7W_RAhBCHm7lCKu0EfJlni070CjSoXiWjE\" target=\"_blank\">https:\/\/doi.org\/10.1038\/nrcardio.2017.172<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1920&#8217;li y\u0131llarda, Amerika bozk\u0131rlar\u0131nda ya\u015fayan \u00e7ift\u00e7iler esrarengiz bir olayla kar\u015f\u0131la\u015ft\u0131lar: S\u0131\u011f\u0131r s\u00fcr\u00fcleri anlam veremedikleri bir nedenden dolay\u0131 ya\u015fam\u0131n\u0131 yitirmekteydi. Olay<\/p>\n","protected":false},"author":207540708,"featured_media":396,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_crdt_document":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"categories":[45541],"tags":[],"class_list":["post-394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-duyurular"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>KAR\u0130YER\u0130NE FARE ZEH\u0130R\u0130 OLARAK BA\u015eLAYAN \u0130LA\u00c7: WARFAR\u0130N - Eczac\u0131 Bilgi Payla\u015f\u0131m ve Dayan\u0131\u015fma Derne\u011fi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/eczbilgipaylasim.com\/?p=394\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"KAR\u0130YER\u0130NE FARE ZEH\u0130R\u0130 OLARAK BA\u015eLAYAN \u0130LA\u00c7: WARFAR\u0130N - Eczac\u0131 Bilgi Payla\u015f\u0131m ve Dayan\u0131\u015fma Derne\u011fi\" \/>\n<meta property=\"og:description\" content=\"1920&#8217;li y\u0131llarda, Amerika bozk\u0131rlar\u0131nda ya\u015fayan \u00e7ift\u00e7iler esrarengiz bir olayla kar\u015f\u0131la\u015ft\u0131lar: S\u0131\u011f\u0131r s\u00fcr\u00fcleri anlam veremedikleri bir nedenden dolay\u0131 ya\u015fam\u0131n\u0131 yitirmekteydi. 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